Sulfasalazine 500 is composed of the antibacterial substance sulfapyridine and 5-aminosalicylic acid, and by reducing inflammation and suppressing the immune system, it helps to improve the symptoms of inflammatory diseases... In fact, this pill is not a treatment for inflammatory bowel diseases, but it plays an effective role in reducing the symptoms caused by it and increasing the time between attacks..

Learn more: Cimetidine 200 tablets for What is it?

The mechanism of action of Sulfasalazine 500 tablets

The mechanism of action of sulfasalazine depends on its ability to reduce inflammation and modulate the immune response in the body.... After taking this drug in the large intestine, it is broken down into 2 active compounds, sulfapyridine and 5-aminosalicylic acid... Sulfasalazine passes through the stomach and small intestine and finally breaks the large bacteria in the chemical test, then it breaks down the bacteria in their test. It acts on the intestinal wall and prevents the production of inflammatory mediators such as prostaglandins and leukotrienes... This substance plays an important role in inhibiting the production of inflammatory chemicals such as inflammation (TNF) of the intestine) and has little systemic absorption..

Learn more: Meborin tablets

What is Sulfasalazine 500 tablets for?

If you are curious to know what sulfasalazine 500 tablets are useful for, we must say that this tablet is prescribed for the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease, and helps to improve their symptoms by reducing intestinal inflammation..

Also, the doctor may use sulfasalazine tablets to treat joint rheumatism (rheumatoid arthritis). This tablet has anti-inflammatory and immune-modulating properties. Therefore, it is prescribed to reduce inflammation, pain and swelling caused by rheumatoid arthritis, especially in people who have not responded well to non-steroidal anti-inflammatory drugs or biological drugs.

Method of taking sulfasalazine tablets

This drug must be prescribed by a specialist doctor.... The doctor determines the dosage based on the age, type of disease, severity of symptoms and health status of each person.... First, the drug consumption starts with the lowest dose and if necessary, the doctor increases it gradually.... Also, the dosage of sulfasalazine tablets in children should be determined based on their weight.

Other important points for taking sulfasalazine include the following:

• Take the medicine completely until the end of the treatment period.
• To avoid digestive irritation, take the pill with a full glass of water after a meal.
• This medicine should be swallowed whole.. So avoid crushing, breaking or chewing it.
To reduce the possibility of side effects such as nausea, the dose of the drug is gradually increased. Therefore, under no circumstances, do not take 2 doses of the drug at the same time.
• The doctor usually divides the daily dose into 2 to 4 times.. So avoid changing the drug dose arbitrarily.
• If you feel better after taking a few doses of the medicine, avoid stopping the pill arbitrarily.
• Drink plenty of fluids during treatment with sulfasalazine tablets to reduce the possibility of side effects such as kidney stones (unless your doctor has ordered otherwise)
• If you forget to take a dose, take the missed dose as soon as you remember... However, if the next dose is close (less than four hours), you can skip the missed dose and continue taking the medicine as directed.
• During the treatment with this drug, the doctor prescribes periodic blood and liver function tests, which you should take seriously to check the side effects of the drug.
• Salazopyrin is the foreign brand name of sulfasalazine tablets... If you want to buy this medicine, be sure to consult your doctor about its usage method.

Learn more: What is prednisolone 5 tablets for?

The best time to take Sulfasalazine tablets

The best time to take this pill depends on the treatment plan and the specific conditions of each patient, but it is usually recommended to take sulfasalazine with or immediately after food. This method helps reduce digestive side effects such as nausea and stomach upset.... It is also very important to take the medicine at a certain time of the day so that a constant dose remains in the body.

Learn more: Pancreatin tablets

Precautions and contraindications of Sulfasalazine

This pill should be used with caution in the presence of the following conditions and diseases and may be contraindicated in some cases:

• Allergy to sulfasalazine and its compounds
• Liver and kidney disease
History of bowel and urinary tract obstruction
• Severe allergy
Blood disorders such as aplastic anemia and porphyria
• Asthma
• Genetic problems such as G6PD enzyme deficiency

Learn more: Cladinium C

Sulfasalazine tablets in pregnancy and breastfeeding

The use of this pill during pregnancy should be done with caution and when necessary under the supervision of a doctor.... Sulfasalazine is placed in category B of pregnancy drugs.... This means that animal studies have not shown any particular risk to the fetus, but currently there is not enough human research on its effect on the fetus..

On the other hand, the ingredients of sulfasalazine may reduce the amount of folic acid in the mother's body... This complication can cause spinal defects such as spinal cord protrusion in the baby.... Therefore, it is recommended to avoid using this drug during pregnancy without consulting a doctor, and if you notice your pregnancy during the treatment period with sulfasalazine, you should definitely consult a doctor..

Also, using sulfasalazine tablets during pregnancy Breastfeeding is not recommended.. Because its ingredients are transferred to the baby through breast milk and can lead to side effects such as bloody stools or diarrhea in the baby.

Learn more: bismuth subcitrate tablets

Side effects of sulfasalazine tablets

This pill may have possible side effects like any other drug, which include the following:

Common side effects

Common risks and side effects of this pill are usually mild and get better after a few days:

• Decreased appetite
• Headache
• Nausea
• vomiting
• stomach pain
• Skin sensitivity
• Itching
• dizziness

Serious side effects

The following symptoms are serious risks of sulfasalazine and you should tell your doctor immediately if you experience any of them:

• decrease in urine volume
• Skin problems such as blisters, red or purple skin rashes
• Blood problems
Sore throat, fever and paleness
• Liver problems with symptoms such as yellow skin and eyes

Learn more: Demetron tablets

Drug interaction of sulfasalazine

Drug interactions can reduce the effectiveness of this pill or increase the likelihood of side effects... Drugs that may interact with sulfasalazine. They are:

• Folic acid
• Messalamin
• Digoxin
Hexamethylenetetramine
• 4-aminobenzoic acid or oral PABA

Guide to see a doctor

Sulfasalazine tablets are one of the useful drugs in the treatment of inflammatory bowel diseases such as ulcerative colitis and play an effective role in reducing the symptoms of Crohn's disease.. Also, some doctors prescribe this tablet to relieve inflammation, pain and swelling caused by rheumatism of the joints.

In this article from GCORP LLC magazine, we talked in detail about the application, side effects and method of taking this drug.... If you have any questions about the safety and effectiveness of sulfasalazine according to your specific conditions, you can visit the website of GCORP LLC and consult with the best gas specialist doctor, including gas specialist doctor.. online.... Also, GCORP LLC has provided you with the possibility to make an appointment with the specialist of your choice through the online appointment system.

Frequently Asked Questions

Sources: Drugs webmd